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Analysis of the BACE1 and Clusterin Genes Expression Levels in Alzheimer’s Disease
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Original Investigation
VOLUME: 9 ISSUE: 1
P: 45-49
April 2019

Analysis of the BACE1 and Clusterin Genes Expression Levels in Alzheimer’s Disease

J Acad Res Med 2019;9(1):45-49
DOI: 10.5152/jarem.2019.2671
Hani Alsaadoni 1
Burcu Çaykara 1
Sadrettin Pençe 1
Saffet Tüzgen 2
Halime Hanım Pençe 3
1. Department of Molecular Medicine, İstanbul University Aziz Sancar Institute of Experimental Medicine (ASDETAE), İstanbul, Turkey
2. Department of Neurosurgery, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey
3. Department of Medical Biochemistry, University of Health Sciences, School of Medicine, İstanbul, Turkey
No information available.
No information available
Received Date: 06.12.2018
Accepted Date: 15.01.2019
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ABSTRACT

Conclusion:

Our study showed that the blood mRNA levels of the BACE1 and CLU genes were associated with AD.

Results:

The BACE1 and CLU genes were found 14-fold and 13-fold more expressed in the blood of the AD group than on the control group, respectively.

Methods:

The expression levels of CLU and BACE1 in blood samples of subjects were examined using the real-time polymerase chain reaction (RT-PCR). The expression levels of patient and control groups were calculated using the 2-ΔΔCt method. The Statistical Package for Social Sciences (SPSS) version 22 (IBM Corp., Armonk, NY, USA) was used for statistical analysis, and a p of ˂0.05 was accepted as statistically significant.

Objective:

This study aimed to explore the mRNA expressions of the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and clusterin (CLU) genes in blood samples of patients with Alzheimer’s disease (AD) and healthy subjects.