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E-ISSN: 2147-1894
Effects of JAM-A rs790056 and LFA-1 rs8058823 Variations on Kidney Cancer
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Original Investigation
VOLUME: 9 ISSUE: 1
P: 41-44
December 2019

Effects of JAM-A rs790056 and LFA-1 rs8058823 Variations on Kidney Cancer

DOI: 10.5152/jarem.2019.2891
Halime Hanım Pençe 1
Burcu Çaykara 2
Sadrettin Pençe 2
Bengü Tokat 2
Alper Ötünçtemur 3
1. Department of Medical Biochemistry, University of Health Sciences School of Medicine, İstanbul, Turkey
2. Department of Molecular Medicine, İstanbul University Aziz Sancar Institute of Experimental Medicine (ASDETAE), İstanbul, Turkey
3. Department of Urology, University of Health Sciences Okmeydanı Training and Research Hospital, İstanbul, Turkey
No information available.
No information available
Received Date: 18.03.2019
Accepted Date: 17.04.2019
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ABSTRACT

Conclusion:

In our study, it was observed that JAM-A rs790056 and LFA-1 rs8058823 had no effect on kidney cancer.

Results:

Genotype and allele distributions of JAM-A rs790056 and LFA-1 rs8058823 were similar in tumor and healthy peripheral tissues (p>0.05).

Methods:

DNA was isolated from 50 renal tumors and 50 healthy peripheral tissues. Gene variants of DNA samples were analyzed using the polymerase chain reaction and restriction fragment length polymorphism methods. The Statistical Package for Social Sciences version 22.0 (IBM Corp., Armonk, NY, USA) was used for statistical analysis, and p<0.05 was accepted as statistically significant.

Objective:

Kidney cancer is a type of cancer that includes different histology subgroups, and the number of kidney cancer cases is expected to increase. It has been found that the junctional adhesion molecule A (JAM-A) as a transmembrane glycoprotein is associated with cancer characteristics such as invasion, metastasis, and poor prognosis. Therefore, we aimed to investigate the effect of gene variations in JAM-A and its ligand lymphocyte function-related antigen-1 (LFA-1) on kidney cancer.