EN | TR
E-ISSN: 2147-1894
Effects of Perfusion Temperature on Inflammatory Response and Outcome Following Cardiopulmonary Bypass
PDF
Cite
Share
Request
Original Investigation
VOLUME: 2 ISSUE: 1
P: 10-14
April 2012

Effects of Perfusion Temperature on Inflammatory Response and Outcome Following Cardiopulmonary Bypass

J Acad Res Med 2012;2(1):10-14
DOI: 10.5152/jarem.2012.05
Bora Farsak 1
Mehmet Öç 1
Funda Gümüş 2
Bahar Öç 3
Vedat Erentuğ 4
1. Department of Cardiovascular Surgery, Faculty of Medicine, Selçuk University, Konya, Turkey
2. Clinic of Anesthesiology and Reanimation, Bağcılar Education and Research Hospital, İstanbul, Turkey
3. Department of Anesthesiology and Reanimation, Faculty of Medicine, Selçuk University, Konya, Turkey
4. Clinic of Cardiovascular Surgery, Bağcılar Education and Research Hospital, İstanbul, Turkey
No information available.
No information available
Received Date: 15.01.2012
Accepted Date: 18.03.2012
PDF
Cite
Share
Request

ABSTRACT

Objective:

To evaluate the effects of perfusion temperature on inflammatory response, and outcome in patients undergoing open heart surgery.

Methods:

Forty nine patients were assigned to 2 groups, group I (n=24) normothermic cardiopulmonary bypass (CPB) and group II (n=25) hypothermic CPB. Blood samples were collected preoperatively and postoperatively for interleukin-6 (IL6) and high sensitive CRP (hsCRP). Concerning the variables, there were no significant preoperative differences between the groups.

Results:

At the end of CPB, mean plasma levels of IL-6 was significantly lower in the normothermia group (Group 1: 34.0±14.9 vs. Group 2: 53.0±41. p<0.05). At postoperative 12h, IL6 concentrations were 25.2±9.2 in Group 1 and 34.0±21.2 in Group 2 (p>0.05). In 24 h, the IL-6 concentrations were 20.4±8.1 in Group 1 and 29.6±21.1 in Group 2 (p>0.05). High sensitive CRP levels were significantly higher at the end of CPB than the preoperative levels (Group 1: 16.1±3.4 vs. Group 2: 18.5±3.6, p<0.05). At postoperative 12 h and 24 h, hsCRP concentrations declined (Group 1: 12.8±2.6 vs. Group 2: 13.2±2.9 at 12h, p>0.05 and Group 1: 12.3±2.6 vs. Group 2: 14.2±2.8 at 24 h, p>0.05). Normothermic CPB resulted in a shorter CPB time; 63.1 ±19.1min. vs 82.0 ±19.2 min. (p <0.01) and the interval up to extubation was 8.9±2.5 h vs. 11.6±4.6 h (p<0.05). Blood loss was 633.1±390.4 ml vs. 981.8±438.0 ml (p<0.05) and use of blood was 2.7±0.7 packages vs. 4.2±0.5 packages (p<0.01) in Group 1 and Group 2 respectively, as well as the length of ICU stay 2.5±0.5 vs. 4.0±0.6 days, (p<0.01). Length of hospital stay was significantly shorter in the normothermic group 7.2±0.5 days vs. 8.0±0.6 days (p<0.01).

Conclusion:

A strategy of normothermic CPB seems to be as safe as hypothermic CPB and is associated with a reduced inflammatory response and offers a better outcome. (JAREM 2012; 2: 10-4)

Keywords: Normothermic CPB, Hypothermic CPB, Inflamatory response, cardiopulmonary bypass, open heart surgery, CABG

References

2024 ©️ Galenos Publishing House