ABSTRACT

The aim of this study is to evaluate of prognosis of the patients with peritoneal carcinomatosis in metastatic gastric carcinoma.

Eighty-seven patients diagnosed with metastatic gastric adenocarcinoma between January 2005 and August 2014 were retrospectively reviewed. The effect of peritoneal metastasis on overall survival and progression-free survival was assessed.

In univariate analysis, Eastern Cooperative Oncology Group (ECOG) performance status (p=0.04), histologic type (p=0.04) and site of metastasis (p=0.02) were significant prognostic factors for overall survival; favoring ECOG performance status 0-1, histopathologically without mucinous component, patients without peritoneal metastasis respectively. Patients with peritoneal metastasis (HR, 1.681; 95% CI, 1.032-2.739; p=0.037) had worse overall survival in multivariate analysis. ECOG PS≥2 predicted inferior PFS in both univariate (8.1months versus 5.5 months, p=0.001) and multivariate analysis (HR, 2.228; 95% CI, 1.397-3.553; p=0.001).

The presence of peritoneal metastasis in patients with metastatic gastric carcinoma is associated with significantly shorter overall survival compared to patients without peritoneal metastasis.

Keywords: Metastatic gastric cancer, peritoneal metastasis, prognosis