ABSTRACT
The presence of peritoneal metastasis in patients with metastatic gastric carcinoma is associated with significantly shorter overall survival compared to patients without peritoneal metastasis.
In univariate analysis, Eastern Cooperative Oncology Group (ECOG) performance status (p=0.04), histologic type (p=0.04) and site of metastasis (p=0.02) were significant prognostic factors for overall survival; favoring ECOG performance status 0-1, histopathologically without mucinous component, patients without peritoneal metastasis respectively. Patients with peritoneal metastasis (HR, 1.681; 95% CI, 1.032-2.739; p=0.037) had worse overall survival in multivariate analysis. ECOG PS≥2 predicted inferior PFS in both univariate (8.1months versus 5.5 months, p=0.001) and multivariate analysis (HR, 2.228; 95% CI, 1.397-3.553; p=0.001).
Eighty-seven patients diagnosed with metastatic gastric adenocarcinoma between January 2005 and August 2014 were retrospectively reviewed. The effect of peritoneal metastasis on overall survival and progression-free survival was assessed.
The aim of this study is to evaluate of prognosis of the patients with peritoneal carcinomatosis in metastatic gastric carcinoma.